PittsburghV1, Main, Exploration, bibRecord, 000391

Parabiotic model for differentiating local and systemic effects of continuous and intermittent hypoxia.

Identifieur interne : 000391 ( Main/Exploration ); précédent : 000390; suivant : 000392

Parabiotic model for differentiating local and systemic effects of continuous and intermittent hypoxia.

Auteurs : Marta Torres [Espagne] ; Mauricio Rojas [États-Unis] ; Noelia Campillo [Espagne] ; Nayra Cardenes [États-Unis] ; Josep M. Montserrat [Espagne] ; Daniel Navajas [Espagne] ; Ramon Farré [États-Unis]

Source :

Journal of applied physiology (Bethesda, Md. : 1985) [ 1522-1601 ] ; 2015.

RBID : pubmed:25377885

Descripteurs français

KwdFr :
- Animaux, Hypoxie (physiopathologie), Hypoxie (sang), Modèles animaux de maladie humaine, Oxygène (sang), Parabiose, Respiration, Souris.
MESH :
- physiopathologie : Hypoxie.
- sang : Hypoxie, Oxygène.
- Animaux, Modèles animaux de maladie humaine, Parabiose, Respiration, Souris.

English descriptors

KwdEn :
- Animals, Disease Models, Animal, Hypoxia (blood), Hypoxia (physiopathology), Mice, Oxygen (blood), Parabiosis, Respiration.
MESH :
- chemical , blood : Oxygen.
- blood : Hypoxia.
- physiopathology : Hypoxia.
- Animals, Disease Models, Animal, Mice, Parabiosis, Respiration.

Abstract

Hypoxia can be damaging either because cells are directly sensitive to low oxygen pressure in their local microenvironment and/or because they are exposed to circulating factors systemically secreted in response to hypoxia. The conventional hypoxia model, breathing hypoxic air, does not allow one to distinguish between these local and systemic effects. Here we propose and validate a model for differentially applying local and systemic hypoxic challenges in an animal. We used parabiosis, two mice sharing circulation by surgical union through the skin, and tested the hypothesis that when one of the parabionts breathes room air and the other one is subjected to hypoxic air, both mice share systemic circulation but remain normoxic and hypoxic, respectively. We tested two common hypoxic paradigms in 10 parabiotic pairs: continuous hypoxia (10% O2) mimicking chronic lung diseases, and intermittent hypoxia (40 s, 21% O2; 20 s, 5% O2) simulating sleep apnea. Arterial oxygen saturation and oxygen partial pressure at muscle tissue were measured in both parabionts. Effective cross-circulation was assessed by intraperitoneally injecting a dye in one of the parabionts and measuring blood dye concentration in both animals after 2 h. The results confirmed the hypothesis that tissues of the parabiont under room air were perfused with normally oxygenated blood and, at the same time, were exposed to all of the systemic mediators secreted by the other parabiont actually subjected to hypoxia. In conclusion, combination of parabiosis and hypoxic/normoxic air breathing is a novel approach to investigate the effects of local and systemic hypoxia in respiratory diseases.

DOI: 10.1152/japplphysiol.00858.2014
PubMed: 25377885

Affiliations:

Le document en format XML

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<term>Modèles animaux de maladie humaine</term>
<term>Oxygène (sang)</term>
<term>Parabiose</term>
<term>Respiration</term>
<term>Souris</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hypoxia</term>
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<front><div type="abstract" xml:lang="en">Hypoxia can be damaging either because cells are directly sensitive to low oxygen pressure in their local microenvironment and/or because they are exposed to circulating factors systemically secreted in response to hypoxia. The conventional hypoxia model, breathing hypoxic air, does not allow one to distinguish between these local and systemic effects. Here we propose and validate a model for differentially applying local and systemic hypoxic challenges in an animal. We used parabiosis, two mice sharing circulation by surgical union through the skin, and tested the hypothesis that when one of the parabionts breathes room air and the other one is subjected to hypoxic air, both mice share systemic circulation but remain normoxic and hypoxic, respectively. We tested two common hypoxic paradigms in 10 parabiotic pairs: continuous hypoxia (10% O2) mimicking chronic lung diseases, and intermittent hypoxia (40 s, 21% O2; 20 s, 5% O2) simulating sleep apnea. Arterial oxygen saturation and oxygen partial pressure at muscle tissue were measured in both parabionts. Effective cross-circulation was assessed by intraperitoneally injecting a dye in one of the parabionts and measuring blood dye concentration in both animals after 2 h. The results confirmed the hypothesis that tissues of the parabiont under room air were perfused with normally oxygenated blood and, at the same time, were exposed to all of the systemic mediators secreted by the other parabiont actually subjected to hypoxia. In conclusion, combination of parabiosis and hypoxic/normoxic air breathing is a novel approach to investigate the effects of local and systemic hypoxia in respiratory diseases.</div>
</front>
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Parabiotic model for differentiating local and systemic effects of continuous and intermittent hypoxia.

Parabiotic model for differentiating local and systemic effects of continuous and intermittent hypoxia.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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